Abstract: This study selects Baoding Hospital Affiliated to Beijing Children's Hospital, Capital Medical University, as a case to explore optimization strategies for spatial resource utilization in children's hospitals under the persistent growth of patient volumes. Current spatial layouts in hospitals exhibit inefficiencies, such as over-concentration of certain departments, leading to excessive patient flow. This not only compromises patient experience but also results in resource wastage. By constructing a simulation model for verification, this research proposes strategies to optimize the allocation of hospital spatial resources, aiming to alleviate patient congestion, enhance patient experience, and improve healthcare service efficiency. The methodology integrates on-site investigations, physician interviews, and simulations using the AnyLogic software. Results demonstrate that optimizing consultation zone resource allocation and spatial restructuring can significantly improve spatial resource utilization efficiency, reduce patient waiting times, and elevate healthcare service efficiency. This study holds substantial theoretical and practical significance for advancing medical service quality and patient satisfaction.