In this paper, the BIM technology is applied in the design of high-rise residential buildings, to launch analysis and research on several key technologies. A BIM-based multi-disciplinary modeling architectural form and a datum-providing method in collaborative process are introduced in the paper, and a GDAD-PCMIS collaborative management system is developed to meet the needs of multi-party collaboration. A shape-nesting plan-design module is developed, which is able to form various building plans through combining different flexible modules with the fixed modules. An application method of component part based on linkage function is proposed to ensure the unity of component detail drawings and 3D models, as well as a prefabricated component part library is established to embody the accumulation of the component parts. The cost composition of the prefabricated building is also discussed to analyze the impacts of different prefabricated component combinations on the economic benefits of the buildings. The assistive calculation software on the prefabrication rate and assembly rate is also developed to enhance the design efficiency of prefabricated high-rise residential buildings.