This paper introduces anout-of-code high-rise building in Hefei, which is a 172.8m-high reinforced concrete frame-core structure, with 46 floors and 2 floors in basement. In this paper, the author introduces the high-rise building through its selection of the structure, design of foundation, main results of the structural calculations, seismic performance design, seismic elastic-plastic analysis results and the seismic measures, respectively. Analysis shows that the structure meets thecode requirements, and achieves the expected seismic performances.