The Nanning Air and Sea Plaza project is a high-rise building integrating the office building, business center and basement as a whole, with total construction area of 420 thousand square meters. In this construction project, the key points and main difficulties include large construction area, long construction period, large scaled mechanical and electrical engineering, complex system linkage debugging, multiple vertical pipelines, complex professional equipment in all entire professions, and etc. This project takes the BIM technology as the project management and technical measures, covering all aspects of the design and construction of the organization, including joint examination of construction drawings, collaborative design, integrated optimization of pipelines, design development, cost control, VR virtual, and etc. Application of BIM has ensured the successful implementation of the project, solved multiple graph problems of collisions, and finally improved the quality of the project construction and the comprehensive management level of the project.