Deep foundation pit engineering involves complicated geotechnical engineering problems, including the soil properties, supporting structure, groundwater and the surrounding environment. The rationality of the supporting scheme of deep foundation pit directly affects the safety, economy and construction schedule of the supporting structure. The design of deep foundation pit support should consider the site conditions and surrounding environment characteristics. The innovative support is able to solve practical engineering problems, as well as possessing comparative advantages of all aspects. This paper discusses the design scheme of a deep foundation pit support, compares and analyzes the comprehensive benefits of using cast-in-place piles and pipe piles under multi-index through design calculation, construction, deformation monitoring and economic analysis, which is of positive reference significance for similar projects.