As the key component of the national expressway network G59, Guangxi Lipu-Yulin Expressway will apparently improve the capability of China national expressway network, that can extent the North Bay economy to the north as well, promoting the regional economy. In this project, there are some engineering obstacles the large scale and spatial distance, the complicated geological and geographical environment, many regional planning coordination relationships, to the complicated control engineering technology, etc. The Infraworks software is used as the core platform in the project design phase, and the MicroStation software is used as the core platform in the exploration and design phase. First, the application of Apps, the data of road, bridges, and building, etc, are imported into the core platform realizing the multi-source data fusion. Then, the comprehensive advantages of BIM technology are applied to solve the aforementioned obstacles in this project one by one, so as that one realizes BIM integration application from the site survey to the BIM collaborative design and then to the whole process of the construction management. In the construction stage, the construction management system based on design BIM model was independently developed to realize the information management of the construction process. The application of BIM technology in this project covers the stages of investigation, design and construction, forms a set of whole process application process and methods of early application, collaborative design and construction management.