In early September 2017, for better implementing the "13th 5-year Development Plan for Transportation Informationization", and fully playing the role of modern information technology in the project management, the Ministry of Transport in China decided to carry out construction of BIM Technology Application Demonstration Project in the field of highway industry, to improve the level of highway management and construction. The reconstruction and expansion project of Laiwu-Linyi (Lusujie) section of the Beijing-Shanghai Expressway becomes one of the five demonstration projects, with the task of project management demonstration of using the BIM technology. Considering the characteristics of the reconstruction and expansion project, this paper explores the whole life-cycle BIM application in the highway reconstruction and expansion, aiming at guiding the on-site construction. Through the practice of BIM application in the life-cycle construction of highway reconstruction and expansion project, a comprehensive application method in highway reconstruction and expansion has been concluded, providing experiences for the following-up highway reconstruction and expansion projects in BIM application in the infrastructure field.