With the progress of science and technology and the development of society, new public buildings are gradually showing the characteristics of large area, complex functions and diversified shapes, which puts forward higher requirements for the construction industry. How to use information technology to help construction and production has become the direction of people′s exploration. Since the concept of intelligent construction was put forward, people have never stopped researching on it. After nearly 20 years of development, BIM technology has pushed building informatization to a new height and provided a new direction for intelligent construction. Taking Chengdu nature museum as an example, this paper introduces the research and application of BIM technology in the process of intelligent construction of large-scale special-shaped public buildings from six aspects: standardized model building, construction organization design, steel structure construction, mechanical and electrical installation engineering construction, curtain wall construction and BIM platform application, which provides solutions for intelligent construction to assist construction and production.