Assembly building has been vigorously promoted due to its convenient construction and green environmental protection. As a key link in the construction process of prefabricated construction, hoisting operation involves many safety management elements and complex relationships. The current hoisting safety risk management methods still have problems such as low intelligence level, unguaranteed prediction accuracy, and unreal-time control of safety management factors. In view of the above hoisting safety risk management problems, this paper introduces the concept of digital twin into the field of hoisting safety risk management, analyzes the inducing factors of hoisting safety risk, builds a digital twin framework for hoisting safety management, and expounds the operation mechanism of digital twin model. And based on the key problem of digital twin modeling, the modeling methods of physical hoisting process, virtual hoisting process and virtual and real information interaction are proposed, which have been put into practice in a project to verify the effectiveness of the method, providing theoretical support and technical support for the application of digital twin in hoisting safety risk management.