In order to analyze the feasibility of BIM technology in the field of clean decoration and mechanical and electrical installation, Application points based on BIM technology in deepening design of mechanical and electrical engineering, The method of parametric control and fine modeling is combined, Research BIM technology in GMP clean engineering construction application. In this paper, through the specific application of BIM technology in clean room decoration and mechanical and electrical installation, it is concluded that BIM technology has remarkable effect in improving the integration of various professional construction, strengthening the connection between design and construction, and has outstanding advantages in providing all-round and multi-perspective solutions in actual construction. It provides effective reference for the application of BIM technology in the construction and installation of clean engineering.