Nowdays, the construction of Large Bridge brings serious challenge to Project Management.This paper analyzed the challenge of managing a Large Bridge construction project basis the Project of Ying-wu-zhou Bridge, and put forth the targets of building the Controlling Information System of the Ying-wu-zhou Bridge Project in allusion to the characteristics of the project.The ending of the paper elaborated on the structure, function and application in the Ying-wu-zhou Bridge Project of the Controlling Information System.