Space fine design for frame-supported joints and construction control of a high-rise building with box transfer story was introduced in this paper.According to the conditions beyond code-specification, more strict anti-seismic measures than the current criterions were adopted, and a performance-based seismic design method was used to design the key components; Through the fine finite element analysis of box transfer story, the overall effect of component space was investigated; According to the current problems which existed in design and construction of transfer story, three-dimensional space fine design for frame-supported joints and strict construction control measures were used in design.Practice shows that the adopted measures in design and construction control can effectively solve the technical problems, such as the intensive construction of reinforcement for frame-supported transferring structure and the quality of construction, which can ensure the structure to achieve the earthquake performance objectives.