Abstract: When exposed to fire, the components with high sensitivity are easy to initiate continuous collapse of structure, resulting in reduction of the structural safety. Therefore, the protection should be strengthened in advance. In order to determine the sensitive components of the steel frame structure that may cause the continuous collapse when fire occurs, this paper proposes a calculation method to determine the sensitive component of steel frame structure under high temperature. The finite element software, ANSYS, is used for numerical simulation to extract the stress values of components under loadings of different temperatures, and to obtain the sensitivity coefficient of components at high temperature. Finally, the most sensitive components in the structure can be identified.