Abstract: Structures are often subjected to multiple earthquakes.However, at present, the domestic seismic design specifications in China always consider the impact of single earthquake event, and ignore the response of the bridge structure under the action with multiple earthquakes.In view of this, the authors take the Qiumohe River Bridge as a case study example, to conduct numerical simulation of traditional and cumulative incremental dynamic analysis (IDA) of hollow pier circular end of railway bridge by using the seismic analysis software, OpenSees.The influence of multiple ground motions is studied by comparing displacement responses in two cases.The results show that:(1)The round-ended hollow pier of the railway is soft and the high-order vibration mode is obvious.The maximum displacement and residual displacement of the structure increase with the increase of the peak acceleration.(2)Compared with the single earthquake, the maximum displacement and residual displacement of the structure are both larger with multiple earthquakes.(3)There are two different analysis methods for the maximum displacement response of the structure.When the structure is in an elastic state, the difference is not obvious; and when the structure is in the elastoplastic state, the difference is not negligible.However, for residual displacement, the difference is obvious and cannot be ignored.