Abstract: Concrete shrinkage and creep can be affected by many factors, including environmental humidity, concrete strength, theoretical thickness, loading age, etc.This paper takes a reinforced concrete column as an example, and reports the parameter analysis using ANSYS on it.The effect of various factors on the concrete shrinkage and creep are discussed and studied.Also, an orthogonal experimental design method is used to analyze the sensitivity of different influencing factors on the concrete shrinkage and creep.The result shows that the environmental humidity is the most effective factor influencing the shrinkage and creep, followed by loading age, then concrete strength, the least effective factor is the theoretical thickness.