Abstract: The Jiangbei new district talent apartment (No.1 plot) project in Nanjing is the first EPC management project with an architecture design firm as the leading role in the Jiangbei new area, Nanjing. The project applies both the BIM collaborative platform and the 5D platform as the core tools in the design and construction stages, and integrates a number of special technologies to realize the whole progress BIM application from design to construction. This paper sorts out and mines the advantages and characteristics of BIM application under EPC mode, and summarizes the experience and lessons of BIM application for whole process management in the project, which has made a useful exploration for improving the whole process management efficiency of BIM and the technical quality of virtual construction project, achieving the goal of green, healthy and intelligent centenary building.