Abstract: The construction project of Shenzhen Medical Device Testing and Biomedical Safety Evaluation Center concentrates all kinds of laboratories and experimental animal rooms in the same building. It is the largest, most complex and most widely used high-rise experimental building in the national drug inspection system. However, the site of the construction project is narrow, and the pipelines of mechanical and electrical equipment are intricate, and there are many professional subcontractors, difficult coordination and construction management. The construction project is based on the guidelines and normative documents of Bureau Public Works Of Shenzhen Municipality and combines the objectives to establish a management system based on BIM technology, clarify the responsibilities of all parties involved in the implementation of BIM and standardize the implementation process of BIM, which provides guarantee for the high quality construction of the project, realizes the integrated and comprehensive application of BIM technology oriented to the whole life cycle in urban construction projects. It also provides a demonstration basis for the follow-up similar projects to promote the application and management of BIM technology.