Abstract: The development of intelligent building and the construction of new engineering requires the cultivation of interdisciplinary talents to meet the needs of industrial upgrading. At present, some colleges and universities have carried out the exploration in the major of intelligent building for civil engineering construction, but there are few researches on the cultivation of intelligent talents for the major of Water Science and Engineering. Based on the research of colleges and enterprises, literature, and graduates, the knowledge and skill requirements of intelligent talents for Water Science and Engineering are mastered, and on this basis, the course group of intelligent talents for Water Science and Engineering is designed. By combining new courses with integrated courses, new courses such as BIM application technology and software training, Python language programming, IoT technology, database technology, web crawler and data analysis are set up, and new information technology is integrated into existing professional courses, so as to train intelligent talents to serve the construction of smart water system.