Abstract: This paper analyzes the difficulties encountered in the process of prefabricated in the machine room from four aspects of design, measurement, transportation and installation. Then, from five stages of deepening design preparation, deepening design, module processing, module transportation, and field prefabricated, this paper expounds how to take different measures to prevent and correct the deviation. Combined with the practical application of the project, the construction method of prefabricated machine room based on BIM technology in complex environment is introduced.