Abstract: At present, China′s construction industry urgently needs to be developed into industrialization, informatization, and intelligentization. But the serious shortage of integrated talents for pre-cast building and BIM technology has become a bottleneck. In view of the existing shortage for the theory teaching and practice teaching, practice teaching goals of design, production and construction in pre-cast building BIM application were being proposed through the combination of OBE concept and industry demands. By using CDIO engineering education mode and case driven method, practice teaching framework of assembly building integrated BIM technology is being established. Through teaching case analysis and students′feedback, it proves that this practice system can effectively fill the gaps in pre-cast building theory teaching, and significantly improve students′ comprehensive ability to use BIM technology to solve the issues in pre-cast building design, production and construction.