Abstract: At present, the cost pressure of asset management, information management, personnel and site management, energy consumption management, medical waste management and other aspects of domestic large-scale hospitals is increasing year by year. The equipment management and control system lacks functions such as data analysis, quality monitoring, prediction simulation, etc. It brings significant challenges to the operation and maintenance of hospital facilities. In order to ensure the normal operation of medical buildings, the building facility management should develop in a more intelligent direction. The intelligent operation and maintenance of medical projects is an important neural network node that reflects the ubiquity of urban intelligence, and is an important part of smart city construction, which is worthy of special research. This paper shows the operation and maintenance application for large-scale comprehensive medical projects through the cloud processing of the hospital BIM model. This paper has discussed the method, specific functions and future value of intelligent operation and maintenance of medical projects based on BIM model, so as to provide reference for the operation and maintenance of related types of construction projects.