Abstract: This study focuses on the problem of relying on engineering experience, consuming a lot of manpower, and having personal biases in route fitting in waterway regulation projects. By comprehensively collecting relevant engineering data, such as terrain, imagery, hydrology, etc., and utilizing the open-source nature of domestic GIS platforms, we analyze and process the data. Specifically, we use terrain imagery data to draw auxiliary lines based on river channel trends and calculate the depth of the waterway channel to obtain the talweg. Use the least squares method to fit the deep sea line to obtain the initial design route and construct a navigation trough triangulation model. After calculating the intersection line through a triangulation network, the design route is repeatedly adjusted, and the recommended route is determined based on the comprehensive curvature and intersection range of the waterway. The research results indicate that this method can quickly and efficiently assist in route planning and design, compensating for the problem of insufficient comprehensive and accurate consideration of complex factors in manual route selection. This study has certain reference value for promoting the application of GIS technology in the field of waterway engineering.