Abstract: With the rapid development of the construction industry, EPC mode has become the leading paradigm of engineering contracting. BIM, as a visualization and integrated information management technology, is widely used in EPC projects. However, there are also defects of information fragmentation and operation disconnection in the actual application process of this technology. As a new derivative model of EPC model, EPC+O organically integrates the key links of the whole life cycle of buildings such as design, procurement, construction and operation and maintenance. Through deconstructing all aspects of EPC+O management mode, the EPC+O integrated design innovation model is proposed, which includes the whole process of design, construction, operation and maintenance business data. Under EPC+O construction management mode, the key technology and implementation path of linkage and sharing of business system data and BIM model are expounded, and the case application demonstration and verification are carried out based on the construction of a hospital in Jinan City. The conclusion fully embodies the integrated linkage effect of EPC+O mode, achieves the purpose of reducing cost and increasing efficiency under the premise of ensuring construction quality, and provides ideas and schemes for the exploration of new construction mode of engineering.