Abstract: The crime and public safety in urban life is one of the most important public urban issues with the development of social market economic. As the large industrial parks which are the centers of industry-academic-research are significantly built, the crime prevention in these large industrial parks becomes more and more important. Closed-circuit television and guard patrol system are the major methods to prevent the crime through environment design. On the basis of environmental design and safe planning of large industrial park, this paper presents a mathematical model on the guard patrol system of large industrial park. Firstly, according to the distributions of buildings, roads, and sidewalks, the weak regions (relatively un-safe regions) can be obtained through the quantitative analysis of visibility, accessibility, and characteristic in the current site. Then, the track points of guard patrol system can be confirmed according to these weak regions. Finally, through the genetic algorithm, the tracks of guard patrol system are topologically optimized, and the best optimized guard patrol track is obtained. The case study illustrates the efficiency and accuracy of the proposed method.