Abstract: Large and complex biomimetic structures are very difficult to design.Advance CAD/CAE technologies are gradually applied to the construction field and provide a useful solution for the structural design of biomime-tic constructions.The technologies of virtual simulation were extensively used in the project of Himalayan Art Cen-ter in Shanghai, which is very complex biomimetic structure.CATIA was used to accurately build up the complex curved surfaces.The grid model was generated by HYPERMESH and inputed into ANSYS/SAP/ABAQUS to carry out the different analysis for different purposes.The structural design was completed very well.The solution could be tIle reference for the same kinds of biomimetic construction.