Modern technologic progress and increasingly fierce market competition have stimulated the owner, designer and contractor to initiate a new technological revolution of BIM and 3D printing in the building industry. BIM application plays a more and more important role in the building′s design and construction with the effects of cost reduction, quality improvement and construction period shortening, especially for the complex large-scale projects. There are some difficulties in conducting the project of Urumchi International Highway-railway Combined Passenger Station, such as the short construction period and the great variety of precision prefabricated components. Therefore, our BIM team started using BIM at the early design stage and then continued to the production and construction phases, achieving an efficient management working pattern. This paper firstly focuses on the technical measures, workflow and coordination mechanism established during the starting phase of the project. Following that, it introduces the means of realizing the targets, solving the problems and increasing the accuracy. Finally, the application effects of BIM are concluded and analyzed while some optimization measures are suggested in the future.