With novel design and unique shape, Sanya Forum Permanent Site Project aims to meet the requirements of the highest level of domestic and international political and financial conference of exhibition, which is of high design as well as implementation difficulty. This article comprehensively and systematically introduces the organization mode and application of BIM-based design in this project. From the primary design to later period of construction cooperation, BIM-based design plays an irreplaceable role in the process of coping with civil engineering location and comprehensive pipeline design of complicated form. Especially when confronting with the most complex curtain wall system without mathematical rules, BIM renders to the close combination of design, production and construction and works effectively. Meanwhile, BIM-based design optimizes internal clear height green building-related design. The final completion also shows that BIM-based design not only completes the design task successfully, but also reaches high-level accomplishments.