This paper establishes an ideal model using CFD software by taking the dominant wind direction and speed as the initial condition in Xiamen to simulate the pollutant diffusion range of garbage transfer station. The results shows that the concentration of the odor pollutant was greater than the allowable value in the regional range of sixty meters, which is seen as a basis to guide the general layout. Through establishing an actual model and simulate calculation considering the sensitive building around the garbage transfer station, the result shows that, under the domain wind direction of the summer and winter, some sensitive buildings would be easily polluted, but with small pollutant concentration meeting the regulatory requirements. However, under the static wind of summer, the pollutant concentration of the residential buildings in the northwest and southwest directions would become over the standard requirements, and technical measures should be adopted to reduce the pollutant production of the garbage transfer station. After the adoption, the pollutant concentration of the residential buildings in the northwest and southwest reduces significantly, and meets the regulatory requirements.