The structural seismic design of the high-rise office building of Shenglong Square in Zhengzhou was introduced in this paper. According to the conditions, beyond code-specification, more strict anti-seismic measures than the current criterions and performance-based seismic design were adopted. Meanwhile, the emphasis and difficulty in the desigh and analysis of two-way hollow-ribbed floor are emphatically introduced.The space fine design and strict construction control measures were used to design the key components like section steel beam-column joints, which can ensure the structure to achieve the earthquake performance objectives and meet the requirements of the current code.