The article introduces the background of informatization in quality and safety Supervision of deep excavation engineering. This study suggests applying information technology as a basic approach and method to Quality and Safety Supervision System in Deep Excavation Engineering (QSSSDEE). Based on the Modern Management Principles, Control Theory and Information Theory, this study fulfills the framework design for QSSSDEE, and designs the systemic structures and functions to service government supervision organizations and construction units. In the end, according to Wuhan Quality Supervision Station of Construction Project, the authors presents a discussion on the development realization process, function system, application of QSSSDEE, and summarizes the effects in the application of the system.