The project of Shandong New Science and Technology Museum is characterized by unique project shape, with difficulties in construction, tight construction period, large scale of mechanical and electrical engineering, and exquisite interior decoration. The project adopts mixed steel structure, cast-in-place and prefabrication to meet the unique requirements of large space, large span and building shape. In the process of construction, there are some problems existed including complicated management and distortion of construction data. Therefore, through the application research of BIM Technology, this project has realized the construction of BIM model, the collision inspection and optimization of electromechanical pipelines, and the lapping of complex nodes of steel structure. At the same time, the intelligent construction system is also used to realize the transparent management of the project and promote the green management and intelligent construction of Jinan City.