In order to study the application technology of ATB-25 asphalt stabilized macadam mixture on asphalt pavement in depth, this paper firstly selected the raw materials and grading of the test, and designed the target mix ratio of ATB-25 through the Marshall test. The road performance of ATB-25 mixture was studied through indoor test to determine the high temperature stability, low temperature crack resistance and water stability. In view of the ATB-25 asphalt stabilized macadam mixture, the construction technology of ATB-25 upper base is also discussed from different aspects, from the beginning of mixing to the joint treatment after the completion of rolling. The results show that the best oil-stone ratio of ATB-25 asphalt stabilized macadam mixture production ratio is 3.7%. The ATB-25 asphalt stabilized macadam mixture possesses good road performances, and can be applied to the base layer on asphalt pavement. The study result is of great significance to improve the structural performance of asphalt pavement and prevent the occurrence of reflective cracks in the base layer.