Shanghai Oriental Hospital renovation and expansion project is very complicated due to the demand of ensuring the uninterrupted operation of the old building, the large number of mechanical and electrical systems, the difficulty of construction coordination, and the high requirements of operation and maintenance management. The paper summarizes the process and results of the comprehensive application of BIM technology. This paper focuses on three phases of application, i.e. the critical BIM application in construction period; the BIM model transformation across different stages; and the operation & maintenance phase BIM in-depth application. Through the whole process, it delivered a digital twin of the hospital′s new building, which achieves the visualization of the process of the building′s big data and the flexibilities. Finally, it has concluded the problems during the BIM implementations and has forecasted the future perspectives, which offers method to improve the qualities of model delivery, to improve the quality of information, and to expend the scope of the BIM implementations.