The mechanical and electrical installation engineering of subway station involves ventilation and air conditioning, water supply and drainage and fire-fighting, low-voltage distribution and lighting, and weak current systems. The comprehensive arrangement of four major professional pipelines are the difficult part of the construction design stage. The line between different professional configuration designs needs to meet design and construction specifications and maintenance requirements. This article mainly discusses the collision between professional models and introduces professional model collision point classification, collision detection process, setting of test condition, and collision preparation of reports. From the summaries of the reports of Suyuan station, it shows that air duct, the building structure and electric bridge need to be considered much more than others. In the end, the article summerizes the application prospect and existing problems of BIM technology in electromechanical integrated pipeline configuration of subway stations.